Product Name : Acetylcysteine Injection IP 200mg/ml
Brand Name : ACEBRIL INJ
Strength : 200mg
Manufacturer : Mediclock Healthcare Pvt. Ltd.
Packing : 5*5ml
Production Capacity : 10 Million Injection/Month
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Acetylcysteine Infusion IP 200mg/ml is sterile, containing 20% w/v acetylcysteine. It is a medicine used basically as an antidote for acetaminophen (paracetamol) overdose. It protects the liver from damage caused by high acetaminophen levels in this context.
The injection should be given via intravenous infusion, preferably with a glucose solution containing 5%. Sodium Chloride 0.9% solution might be used if Glucose 5% isn't appropriate.
The full course of treatment with acetylcysteine involves 3 sequential intravenous mixtures:
Starting stacking portion of 150 mg/kg body weight infused in 200 mL over 60 minutes.
50 mg/kg in 500 mL throughout the next 4 hours.
100 mg/kg in 1 liter throughout the next 16 hours.
The patient should consequently get a total of 300 mg/kg over 21 hours.
Children should be treated with similar portions and routine as adults if the amount of intravenous liquid used should be changed to consider age and weight, as liquid over-burden is a potential risk.
N-acetylcysteine should be infused intravenously, preferably with a glucose solution containing 5%. Sodium Chloride 0.9% solution might be used if Glucose 5% isn't suitable.
A 150 mg/kg loading dose infused for one hour (150 mg/kg/h)
Given as a 50 mg/mL solution at a rate of 3 mL/kg/h.
Dose: 50 mg/kg infused over for 4 hours (12.5 mg/kg/h).
given as a solution containing 6.25 mg/mL at a rate of 2 mL/kg/h.
Dose: 100 mg/kg injected more than 16 hours (6.25 mg/kg/h).
Given as a 6.25 mg/mL arrangement at a rate of 1 mL/kg/h.
The essential advantage of Acetylcysteine Injection IP 200mg/ml is its life-saving role as a cure for acetaminophen overdose. There are two main ways it works:
Several Side Effects of Acetylcysteine injection are as follows:
Combining acetylcysteine with alcohol can increase the risk of nausea, vomiting, migraine, and stomach upset. Both acetylcysteine and alcohol can be harmful to the liver. Combining them can worsen liver damage, particularly in people who already have liver conditions.
If the potential advantages offset the expected risks, acetylcysteine should be used in pregnant women. This decision should be made by a medical services professional considering the seriousness of the lady's condition and the Stage of pregnancy.
It's unknown whether acetylcysteine passes into breast milk. No antagonistic impacts have been reported in breastfed newborn children. Examine the dangers and advantages with your primary care physician before taking acetylcysteine while breastfeeding. They can prompt you on elective breastfeeding procedures or recommend to stop breastfeeding temporarily.
Due to the risk of fluid overload and hyponatremia (low blood sodium), people with kidney disease may require a lower dosage or a slower infusion rate. Checking of kidney function and fluid equilibrium is fundamental all through treatment.
Acetylcysteine can cause side effects in people with liver disease, especially at higher doses. Liver capability tests ought to be firmly observed all through treatment.
Acetylcysteine acts as an antecedent for the blend of glutathione, a crucial cell reinforcement in the liver. Glutathione kills a harmful metabolite (NAPQI) created by acetaminophen overdose, keeping it from harming liver cells. Acetylcysteine overdose drains glutathione levels in the liver. Acetylcysteine directly renews these levels, further helping the body's protection against NAPQI.
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